Phenacetin CAS 62-44-2 An In-depth Look at its Manufacturing and Applications
Phenacetin, with the chemical identifier CAS 62-44-2, is a well-known analgesic and antipyretic compound that has been utilized for decades in pharmaceutical applications. This article delves into the intricacies of its manufacturing process, its chemical properties, and its significance in the industry.
Manufacturing Process
The synthesis of Phenacetin involves a series of chemical reactions starting from the base compound, acetophenone. Through a process known as acetylation, an acetyl group is added to the benzene ring of acetophenone, resulting in the formation of Phenacetin. The reaction typically takes place under controlled conditions, involving precise temperature and pressure management to ensure the purity and efficacy of the final product. The process is carefully monitored by skilled chemists and quality control experts, adhering to stringent Good Manufacturing Practices (GMP) to guarantee safety and consistency.
Chemical Properties
Phenacetin, with a molecular formula of C10H13NO2, is a white, odorless crystalline powder. It is soluble in alcohol and ether but sparingly soluble in water. Its chemical structure makes it an effective pain reliever and fever reducer, although its use has been limited due to potential side effects.
Historical and Contemporary Applications
Phenacetin was first synthesized in 1878 and gained popularity as a non-opioid pain medication
Historical and Contemporary Applications
Phenacetin was first synthesized in 1878 and gained popularity as a non-opioid pain medication

Historical and Contemporary Applications
Phenacetin was first synthesized in 1878 and gained popularity as a non-opioid pain medication
Historical and Contemporary Applications
Phenacetin was first synthesized in 1878 and gained popularity as a non-opioid pain medication
phenacetin cas 62-44-2 manufacturer. However, due to concerns over its association with kidney damage and increased risk of cancer, it was largely replaced by safer alternatives like aspirin, paracetamol, and ibuprofen in the late 20th century. Despite this, Phenacetin still finds some niche applications in modern medicine, primarily in combination formulations for its synergistic effects with other analgesics and as a research compound in pharmaceutical studies.
Manufacturers
CAS 62-44-2 Phenacetin manufacturers are mainly located in countries with strong pharmaceutical industries, such as China, India, and Europe. These manufacturers not only produce Phenacetin but also engage in research and development to improve the compound's safety profile and explore new therapeutic applications. They adhere to strict international standards, ensuring that the product meets the requirements of various regulatory bodies like the USFDA and EU GMP.
In conclusion, while Phenacetin may have lost its mainstream status in the pharmaceutical market, its historical significance and continued use in specialized areas highlight the importance of understanding its manufacturing process and properties. As research continues to evolve, Phenacetin's journey from laboratory to pharmacy shelf underscores the dynamic nature of pharmaceutical science and the constant strive for improved drug safety and efficacy.