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Nov . 09, 2024 10:11 Back to list

Synthesis and Applications of o-Benzylhydroxylamine Hydrochloride in Organic Chemistry



O-Benzylhydroxylamine Hydrochloride Properties, Applications, and Safety


O-Benzylhydroxylamine hydrochloride, with the CAS number 2687-43-6, is a versatile organic compound known for its unique chemical properties and its applications in various fields, including pharmaceuticals and organic synthesis. As a derivative of hydroxylamine, it possesses a benzyl group that enhances its reactivity and utility in organic chemistry.


Chemical Structure and Properties


The structure of o-benzylhydroxylamine consists of a hydroxylamine functional group (-NH2OH) attached to a benzyl group (C6H5-CH2-). This combination imparts specific physical and chemical properties to the compound. O-Benzylhydroxylamine hydrochloride is typically presented as a white to off-white crystalline solid that is soluble in water and alcohol. Its molecular formula is C7H10ClN, and it has a molecular weight of approximately 145.62 g/mol.


The compound's hydroxylamine functionality enables it to act as a nucleophile, making it reactive towards various electrophiles. This reactivity is crucial for its applications in synthetic organic chemistry, particularly in amination reactions and the generation of oxime derivatives.


Applications in Organic Synthesis


One of the primary uses of o-benzylhydroxylamine hydrochloride is in organic synthesis, where it serves as an important building block. It is often used in the preparation of oximes, which are vital intermediates in the synthesis of various pharmaceuticals and agrochemicals. The conversion of carbonyl compounds to oximes is a well-known reaction, and o-benzylhydroxylamine hydrochloride effectively facilitates this transformation.


o-benzylhydroxylamine hydrochloride cas 2687-43-6

Synthesis and Applications of o-Benzylhydroxylamine Hydrochloride in Organic Chemistry

Additionally, o-benzylhydroxylamine hydrochloride finds applications in the field of medicinal chemistry. Due to its ability to form stable complexes with carbonyl-containing compounds, it can be utilized in drug discovery processes. Researchers often employ it in the synthesis of compounds with potential pharmaceutical activity, exploring new therapeutic agents for various diseases.


Safety and Handling


While o-benzylhydroxylamine hydrochloride is a useful reagent, it is essential to handle it with care due to its potential hazards. Like many organic compounds, it can be harmful if ingested, inhaled, or comes into contact with skin. Therefore, appropriate safety measures should be taken when working with this compound, including the use of personal protective equipment such as gloves, goggles, and lab coats.


In case of exposure, it is crucial to follow safety protocols. Inhalation or skin contact should be avoided, and any spills should be cleaned up promptly using proper procedures. Moreover, working in a well-ventilated area or a fume hood is highly recommended to minimize inhalation risks.


Conclusion


O-Benzylhydroxylamine hydrochloride is a significant compound in the realm of organic chemistry, known for its versatility and reactivity. Its ability to act as a nucleophile facilitates important synthetic pathways, particularly in the preparation of oximes and other derivatives. As a key player in pharmaceutical research and organic synthesis, it continues to be an essential reagent for chemists.


Despite its numerous applications, safety should remain a top priority when handling o-benzylhydroxylamine hydrochloride. Proper protocols and precautions will ensure that researchers can benefit from this compound while minimizing risks. As research progresses, there is potential for further innovations and applications of this valuable chemical in various scientific domains.


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