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Nov . 24, 2024 08:58 Back to list

china cas 5086-74-8 tetramisole hydrochloride



Tetramisole Hydrochloride An Overview


Tetramisole hydrochloride, with the chemical formula C10H12N2S·HCl, is a synthetic compound primarily recognized for its anthelmintic (anti-parasitic) properties. It was initially developed as a deworming medication in veterinary medicine, particularly for livestock, and later found applications in human medicine as well. This article explores the characteristics, applications, and significance of tetramisole hydrochloride.


Chemical Characteristics


Tetramisole hydrochloride is a white, crystalline powder that is soluble in water and moderately soluble in alcohol. The compound is classified as a thiol derivative, which contributes to its biological activity. The structure of tetramisole is built around a 2-imidazolidinone ring, which is critical for its pharmacological effects. The hydrochloride form enhances the stability and solubility of the compound, making it easier to formulate into various dosage forms.


Mechanism of Action

Tetramisole acts by interfering with the neuromuscular function of nematodes (roundworms), leading to paralysis and eventual expulsion from the host's body. It selectively targets the parasitic muscles and acetylcholine receptors, thereby disrupting their normal movement and feeding behavior. This mechanism makes tetramisole an effective treatment against a variety of helminth infections, particularly in the gastrointestinal tract.


Medical Applications


china cas 5086-74-8 tetramisole hydrochloride

china cas 5086-74-8 tetramisole hydrochloride

In addition to its use in veterinary medicine, tetramisole has found a place in human medicine, particularly in treating ascariasis and other helminthic infections. It has also been utilized as an immune-modulating agent and, interestingly, as a supplement in some cancer treatments due to its ability to stimulate the immune system. Some studies have suggested that tetramisole may enhance the effectiveness of certain chemotherapy drugs, although more research is necessary in this area.


Safety and Side Effects


While tetramisole is generally well-tolerated, it is not free from side effects. Common adverse reactions include gastrointestinal disturbances, headaches, and dizziness. In rare cases, more severe reactions such as skin rashes or allergic responses may occur. Due to these potential side effects, healthcare providers must consider the risks and benefits when prescribing tetramisole.


Regulatory Status and Availability


Tetramisole hydrochloride is available in several countries with varying regulatory statuses. In some regions, it remains a prescription medication, while in others, it may be available over-the-counter for veterinary use. However, due to concerns about the emergence of drug-resistant parasites, the use of tetramisole and similar anthelmintics should be carefully monitored and regulated.


Conclusion


Tetramisole hydrochloride is a significant compound in the arsenal against parasitic infections. With its dual role as an anthelmintic and potential immune-modulator, it underscores the importance of continued research into its applications beyond traditional uses. As medicine advances, the understanding and utilization of compounds like tetramisole will continue to evolve, ensuring that effective treatment options remain available for managing parasitic diseases in both humans and animals.


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