Understanding Tetramisole Hydrochloride Manufacturers and Applications

Tetramisole hydrochloride, with the CAS number 20586-74-8, is a pharmaceutical compound primarily recognized for its antiparasitic properties. It is widely utilized in both veterinary and human medicine, particularly as an anthelmintic to treat various worm infestations. The following article provides an overview of tetramisole hydrochloride, its applications, and insight into the manufacturers producing this essential compound.

What is Tetramisole Hydrochloride?

Tetramisole hydrochloride is a synthetic derivative of the natural compound levamisole, which was initially developed as a deworming agent for livestock. The compound functions primarily as a selective agonist for nicotinic acetylcholine receptors, causing paralysis in parasitic worms, leading to their expulsion from the host. Its effectiveness has made it popular in veterinary medicine but has also extended its use to human medicine, particularly in treating conditions like ascariasis and hookworm infections.

Applications in Veterinary and Human Medicine

In veterinary medicine, tetramisole is used extensively for cattle, sheep, and other livestock to control parasitic infections, thereby improving overall health and productivity. It is available in various formulations, including injections, oral solutions, and boluses, allowing for ease of administration depending on the animal species and age.

In human medicine, tetramisole hydrochloride has been primarily utilized in the treatment of worm infestations among children in various endemic regions. Furthermore, recent research has uncovered potential immunomodulatory effects of tetramisole, leading to its investigations as an adjunct therapy in certain cancers and immune disorders.

Regulatory Status

Tetramisole hydrochloride is regulated by health authorities in various countries. In some regions, it is available as a prescription medication while being restricted in others due to concerns about resistance and safety. The regulatory landscape plays a crucial role in determining the formulations available and the guidelines for their usage.

Manufacturers of Tetramisole Hydrochloride

The production of tetramisole hydrochloride is carried out by various pharmaceutical manufacturers worldwide. These companies adhere to stringent quality control guidelines to ensure the safety and efficacy of the product. Notable manufacturers include

1. Boehringer Ingelheim - A leading global player in the pharmaceutical market, Boehringer Ingelheim has established a reputation for producing various veterinary and human health products, including tetramisole hydrochloride.

2. BASF - Known for its extensive range of chemical products, BASF has developed formulations containing tetramisole for agricultural and veterinary applications.

3. Huvepharma - A company specializing in veterinary medicines, Huvepharma manufactures tetramisole hydrochloride as part of its antiparasitic offerings for livestock.

4. Chemtura Corporation - Chemtura produces a wide array of specialty chemicals, including tetramisole for both the veterinary and human pharmaceutical sectors.

5. Local Manufacturers - Many countries host numerous smaller manufacturers focused on producing tetramisole hydrochloride, ensuring regional availability and adherence to local health regulations. These manufacturers often cater to local markets, providing tailored formulations to meet specific needs.

Conclusion

Tetramisole hydrochloride (CAS 20586-74-8) remains a vital compound in the pharmaceutical landscape, particularly for its role in combating parasitic infections in both humans and animals. The market comprises a diverse array of manufacturers working tirelessly to deliver high-quality products that adhere to regulatory standards. As research continues to unveil potential new applications and mechanisms of action for tetramisole, its relevance in medical and veterinary practices is likely to persist. Besides actively addressing current parasitic infections, the exploration of tetramisole’s immunomodulatory effects could pave the way for innovative treatments in the future, reinforcing the importance of understanding and producing this significant compound.