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Nov . 07, 2024 10:01 Back to list

Supplier of Amorolfine Hydrochloride CAS 78613-38-4 for Pharmaceutical Applications



Amorolfine Hydrochloride An Overview of CAS 78613-38-4 and Its Suppliers


Amorolfine hydrochloride is a synthetic antifungal agent primarily used in the treatment of fungal infections, particularly those affecting the nails, known as onychomycosis. As a member of the morpholine class of antifungals, amorolfine exhibits a broad spectrum of activity against various dermatophytes, yeast, and molds. Its mechanism of action involves the inhibition of sterol biosynthesis, pivotal for the structural integrity of fungal cell membranes.


Chemical Structure and Properties


Amorolfine hydrochloride, designated with the CAS number 78613-38-4, has a distinct chemical structure that contributes to its antifungal efficacy. The molecular formula for amorolfine is C21H37ClN2O3, and its molar mass is approximately 394.99 g/mol. The compound is generally available as a colorless to pale yellow solution, commonly formulated in nail lacquers or creams for topical application.


Clinical Applications

The primary application of amorolfine hydrochloride is in dermatology, specifically for the treatment of nail infections caused by fungi. It is widely regarded as an effective treatment option for patients who may not respond well to oral antifungal medications due to side effects or contraindications. The topical application allows for the direct delivery of the drug to the site of infection, enhancing its effectiveness while minimizing systemic exposure.


Mechanism of Action


By targeting the enzyme delta-14 reductase and delta-7 sterol reductase, amorolfine interrupts the normal biosynthesis of ergosterol, a crucial component of fungal membranes. This action leads to fungal cell wall disruption, ultimately resulting in cell death. The selectivity of amorolfine for fungal cells over human cells makes it a valuable tool in antifungal therapy, ensuring a favorable safety profile.


amorolfine hydrochloride cas 78613-38-4 supplier

amorolfine hydrochloride cas 78613-38-4 supplier

Market and Suppliers


The demand for amorolfine hydrochloride has been increasing, particularly in regions with high incidences of fungal infections. As a result, several chemical suppliers and pharmaceutical companies produce and distribute this compound. Suppliers of amorolfine hydrochloride vary in their capabilities, offering different formulations, such as nail lacquer, creams, and bulk material for pharmaceutical preparations.


When sourcing amorolfine hydrochloride, it is crucial to partner with reputable suppliers that comply with good manufacturing practices (GMP) and provide quality assurance documentation to verify the purity and potency of the product. Major suppliers are often certified to meet international standards, such as ISO certifications, and can offer comprehensive technical support, including safety data sheets (SDS) and material safety data sheets (MSDS).


Regulatory Considerations


The appropriate regulation of amorolfine hydrochloride falls under various health authorities depending on the region. In Europe, for example, it is classified as a prescription medication, whereas in some parts of the world, it may be available over the counter. Manufacturers and suppliers need to stay informed about changing regulations to ensure compliance.


Conclusion


In summary, amorolfine hydrochloride (CAS 78613-38-4) is a potent antifungal agent with significant clinical utility in treating onychomycosis. Its mechanism of action and favorable safety profile make it a preferred choice for many healthcare providers. As the market for antifungal agents continues to grow, identifying reliable suppliers who can provide high-quality amorolfine hydrochloride is essential for ensuring effective treatment options for patients suffering from fungal nail infections. With ongoing research and development, the scope of applications for amorolfine may expand, further solidifying its role in antifungal therapy.


By staying informed about the latest developments in this field and collaborating with trustworthy suppliers, healthcare practitioners can maintain high standards of care in combatting fungal infections.


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