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Dec . 02, 2024 01:54 Back to list

3-chloropyridine cas 626-60-8



3-Chloropyridine A Comprehensive Overview


Introduction


3-Chloropyridine, with the Chemical Abstracts Service (CAS) number 626-60-8, is an important chemical compound in the field of organic chemistry and pharmaceuticals. This heterocyclic compound features a pyridine ring, a six-membered aromatic ring containing one nitrogen atom, where one of the carbons is substituted with a chlorine atom in the 3-position. The presence of chlorine significantly alters the physical and chemical properties of the compound, making it a valuable building block for various applications.


Chemical Structure and Properties

The molecular formula of 3-chloropyridine is C5H4ClN, which indicates that it consists of five carbon atoms, four hydrogen atoms, one chlorine atom, and one nitrogen atom. Its molecular weight is approximately 131.54 g/mol, and it has a boiling point of about 155-157 °C. The compound is typically a colorless to pale yellow liquid with a characteristic odor, and it is soluble in organic solvents like ethanol and ether but only sparingly soluble in water.


The chlorination at the 3-position of the pyridine ring affects its reactivity and solubility. Chlorine is an electron-withdrawing group, which influences the compound's electrical properties and makes it a suitable substrate for nucleophilic substitution reactions.


Synthesis


3-Chloropyridine can be synthesized through various methods. One common approach involves the chlorination of pyridine in the presence of chlorine gas or other chlorinating agents. The process requires careful control of reaction conditions to avoid over-chlorination or the formation of other isomers. Another synthetic route is through the reaction of 3-hydroxypyridine with thionyl chloride, yielding 3-chloropyridine while generating by-products that can be easily removed.


3-chloropyridine cas 626-60-8

3-chloropyridine cas 626-60-8

Applications


3-Chloropyridine serves as a versatile intermediate in the organic synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows for numerous modifications, leading to further derivatives used in drug development. Notably, it's utilized in the synthesis of compounds that have applications in treating diseases such as cancer, bacterial infections, and neurological disorders.


In the agrochemical industry, 3-chloropyridine is employed in the formulation of herbicides and pesticides. The compound has shown efficacy against various pests and weeds, making it an essential ingredient in modern agriculture. Furthermore, it is involved in the production of materials for dyes, plastics, and other industrial chemicals.


Safety and Handling


As with many chemical substances, proper safety precautions must be observed when handling 3-chloropyridine. It is classified as a harmful and irritant substance; thus, it is advised to wear appropriate personal protective equipment (PPE) such as gloves and goggles. Inhalation or direct contact with skin should be avoided, as it may lead to adverse health effects. Furthermore, due diligence should be employed in the disposal of waste containing 3-chloropyridine, following local regulations and guidelines to prevent environmental contamination.


Conclusion


3-Chloropyridine is a significant compound in the realm of synthetic organic chemistry, with far-reaching implications in drug development and agrochemical formulations. Its unique structural characteristics and reactivity offer numerous possibilities for the creation of more complex molecules. As science advances, the potential applications of 3-chloropyridine will continue to grow, underscoring the importance of understanding its chemical properties, synthesis methods, and safe handling practices. As researchers and industries push the boundaries of chemistry, compounds like 3-chloropyridine will undoubtedly play a crucial role in developing innovative solutions to contemporary challenges in health and agriculture.


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