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Nov . 30, 2024 07:31 Back to list

122453-85-4



The compound with the chemical identifier 122453-85-4, known as Piroxicam beta-cyclodextrin, is an innovative formulation designed to enhance the solubility and bioavailability of Piroxicam, a non-steroidal anti-inflammatory drug (NSAID). This particular compound combines Piroxicam with beta-cyclodextrin to create a complex that minimizes the typically poor water solubility of Piroxicam, thereby improving its therapeutic efficacy.


Piroxicam is widely used in clinical settings for its analgesic and anti-inflammatory properties. It is commonly prescribed for conditions such as arthritis, osteoarthritis, and acute pain. However, one of the significant limitations of Piroxicam is its low solubility in water, which hampers its absorption in the gastrointestinal tract and, consequently, its bioavailability. This challenge has led researchers to explore various carriers and formulations to improve the delivery and effectiveness of this important medication.


The compound with the chemical identifier 122453-85-4, known as Piroxicam beta-cyclodextrin, is an innovative formulation designed to enhance the solubility and bioavailability of Piroxicam, a non-steroidal anti-inflammatory drug (NSAID). This particular compound combines Piroxicam with beta-cyclodextrin to create a complex that minimizes the typically poor water solubility of Piroxicam, thereby improving its therapeutic efficacy.


Apart from the improved solubility, the Piroxicam beta-cyclodextrin complex offers several other advantages. These include increased stability of the drug in various environmental conditions and a reduced risk of gastrointestinal irritation, a common side effect of non-steroidal anti-inflammatory drugs. The beta-cyclodextrin complex may act as a protective carrier that shields Piroxicam from degradation while also minimizing its direct contact with the gastric mucosa.


122453-85-4

122453-85-4

The incorporation of beta-cyclodextrin into pharmaceutical formulations is gaining popularity due to its favorable properties. Moreover, the safety profile of beta-cyclodextrin enhances the overall profile of the Piroxicam formulation, making it a more attractive option for patients who require long-term treatment for chronic pain and inflammatory conditions.


Research studies have shown that the beta-cyclodextrin complex significantly improves the pharmacokinetic properties of Piroxicam, leading to quicker onset of action and extended duration of therapeutic effects. These advancements in formulation technology showcase the importance of drug carriers in overcoming the solubility challenges of existing medications and provide a pathway to developing more effective treatments for pain and inflammation.


In conclusion, the development of Piroxicam beta-cyclodextrin highlights the potential of drug delivery systems to enhance the therapeutic outcomes of conventional medications. By leveraging innovations in pharmaceutical science, healthcare providers can offer improved treatment options that align with patients' needs for efficacy, safety, and quality of life.


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