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Ogo . 16, 2024 23:26 Back to list

Tetramisole Hydrochloride CAS 205086-74-8 A Comprehensive Overview of Its Uses and Properties



Tetramisole Hydrochloride An Overview


Tetramisole hydrochloride, with the chemical formula C11H15N3S·HCl and CAS number 50586-74-8, is a synthetic compound that has been primarily used in both veterinary and human medicine. Initially developed as an anti-parasitic agent, tetramisole has been recognized for its immunomodulatory effects and biological properties, making it an important subject of study in pharmacology and therapeutic applications.


Chemical Structure and Properties

Tetramisole is a member of the imidazothiazole family, characterized by its unique five-membered ring structure containing sulfur and nitrogen atoms. Its hydrochloride form enhances its solubility in water, making it easier to administer in various pharmaceutical preparations. The compound exhibits a melting point around 150°C and is stable under normal conditions, which aids its storage and handling in medical settings.


Mechanism of Action


Tetramisole acts primarily as an anthelmintic, targeting parasitic worms within the host organism. It works by interfering with the neuromuscular activity of the parasites, leading to paralysis and eventual expulsion from the host. Tetramisole is particularly effective against hookworms, roundworms, and other gastrointestinal parasites that afflict both animals and humans.


In addition to its anti-parasitic properties, tetramisole has garnered attention for its immunomodulatory effects. It has been shown to enhance the function of T-lymphocytes and promote the production of antibodies, thus stimulating the immune response. This quality has led to its use as an adjunct therapy in certain cancers and chronic infections, illustrating its versatility as a pharmaceutical agent.


Therapeutic Uses


cas 5086-74-8 tetramisole hydrochloride

cas 5086-74-8 tetramisole hydrochloride

Historically, tetramisole was widely used in veterinary medicine to treat infections caused by parasites in livestock. Its effectiveness and safety profile made it a preferred choice among veterinarians. In humans, it was used to treat parasitic infections, especially in areas where such infections were prevalent. However, its popularity has waned due to the development of more effective and safer alternatives.


Today, tetramisole is more commonly recognized for its role in stimulating the immune system. Research has indicated its potential in improving immune responses in patients undergoing treatment for digestive disorders, autoimmune diseases, and certain types of cancer. Its immunomodulatory properties make it a candidate for further study, especially in the context of personalized medicine.


Side Effects and Considerations


Like any medication, tetramisole hydrochloride may cause side effects. Common adverse reactions include gastrointestinal disturbances, dizziness, and skin rashes. In rare cases, it can lead to more severe reactions, particularly in sensitive individuals. Therefore, healthcare providers must conduct thorough patient assessments before prescribing this medication, ensuring that it is appropriate for the patient's specific condition and overall health status.


Additionally, the use of tetramisole has raised some safety concerns due to potential contamination with harmful substances during manufacturing processes. Hence, regulatory oversight is essential to ensure that any pharmaceutical preparations of tetramisole are produced in compliance with stringent safety and quality standards.


Conclusion


Tetramisole hydrochloride represents an intriguing compound with a rich history in medicine. Its dual role as an anti-parasitic agent and an immunomodulator underscores its importance in both veterinary and human health. As research progresses, further insights into its mechanisms and therapeutic applications may reveal novel ways to utilize tetramisole in clinical practice, potentially improving outcomes for patients with various health conditions. The ongoing exploration of this compound’s properties continues to offer exciting possibilities in the fields of pharmacology and therapeutic development.


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