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ജുലാ . 28, 2024 09:42 Back to list

Exploring the Uses and Effects of Hydroxychloroquine Sulfate CAS 747-36-4 in Medical Treatments



Hydroxychloroquine Sulfate An Overview of Its Uses and Mechanisms


Hydroxychloroquine sulfate, chemically known as 2-[(7-chloroquinolin-4-yl)(ethyl)amino]ethanol sulfate, is a medication that has garnered significant attention in recent years, particularly due to its potential applications in the treatment of various diseases, including malaria, lupus erythematosus, and rheumatoid arthritis. Identified by its CAS number 747-36-4, hydroxychloroquine belongs to a class of drugs known as aminoquinolines and operates primarily as an antimalarial and immunosuppressant.


Hydroxychloroquine Sulfate An Overview of Its Uses and Mechanisms

Beyond its antimalarial activity, hydroxychloroquine is widely utilized in the management of autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). In these conditions, the drug is thought to modulate the immune response, reducing inflammation and preventing flares by inhibiting certain pathways in the immune system. The drug's ability to stabilize lysosomal pH and decrease the production of pro-inflammatory cytokines contributes to its effectiveness in treating these chronic diseases.


hydroxychloroquine sulfate cas747-36-4

hydroxychloroquine sulfate cas747-36-4

The role of hydroxychloroquine in the management of autoimmune conditions has been significantly documented, with numerous studies highlighting its benefits in alleviating symptoms and improving patient quality of life. Patients with SLE, for example, have reported fewer disease flares and a decrease in the frequency of skin rashes and joint pain when treated with hydroxychloroquine. Similarly, in rheumatoid arthritis, the drug serves as a disease-modifying antirheumatic drug (DMARD), helping slow the progression of the disease and joint damage.


In recent years, hydroxychloroquine gained additional attention as a potential treatment for COVID-19. During the early stages of the pandemic, there was considerable interest in its ability to prevent viral replication and modulate the immune response in infected patients. However, subsequent clinical trials yielded conflicting results, leading to a reassessment of its efficacy in this context. While some initial studies suggested potential benefits, larger, more rigorous trials indicated that hydroxychloroquine was not effective in reducing mortality or improving outcomes in COVID-19 patients.


Despite the controversy surrounding its use for COVID-19, hydroxychloroquine remains an essential medication with a well-established role in the treatment of malaria and autoimmune disorders. It is generally well-tolerated, though, like any medication, it carries potential side effects, including gastrointestinal upset, skin reactions, and rare but serious ocular toxicity.


In conclusion, hydroxychloroquine sulfate (CAS 747-36-4) is a versatile medication with significant historical and contemporary relevance in the treatment of malaria and autoimmune diseases such as lupus and rheumatoid arthritis. While its role in the COVID-19 pandemic remains contentious, its efficacy in other indications is well-supported by clinical evidence. As research continues, it is crucial to approach the use of hydroxychloroquine with a balanced understanding of its advantages and limitations, ensuring that patients receive optimal care based on the most current scientific knowledge.


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