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Ное . 01, 2024 10:25 Back to list

Tosyl Chloride Supplier CAS 98-59-9 High Quality Chemical Products for Research and Industry



Tosyl Chloride A Key Intermediate in Organic Synthesis


Tosyl chloride, chemically known as para-toluenesulfonyl chloride, is a versatile compound widely used in organic chemistry. Its CAS number is 98-59-9, and it serves as an essential intermediate in the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals. Manufactured primarily through the sulfonation of toluene, tosyl chloride has emerged as a crucial reagent for various chemical processes.


One of the most significant applications of tosyl chloride is in the production of tosylate esters, which are vital in substitutive nucleophilic reactions. The presence of the sulfonyl group enhances the leaving ability of the corresponding leaving group, making it easier for nucleophiles to attack. This process is crucial for chemists looking to create complex organic molecules efficiently.


Tosyl chloride is typically supplied in a stable, dry form, but it is highly reactive, particularly with amines and alcohols. When reacted with alcohols, it forms alkyl tosylates, which are excellent substrates for nucleophilic substitution. This reaction pathway is frequently employed in the synthesis of pharmaceutical compounds, where precise structural modifications can lead to molecules with desired biological activity.


tosyl chloride cas 98-59-9 manufacturer

tosyl chloride cas 98-59-9 manufacturer

In addition to its ability to modify alcohols and amines, tosyl chloride can also be utilized in the synthesis of sulfonamides—important compounds in medicinal chemistry. The ability to introduce a sulfonyl group into an amine using tosyl chloride allows for the development of new therapies targeting a variety of diseases.


Despite its extensive applications, handling tosyl chloride requires caution. It is corrosive and can cause severe burns upon contact with skin or eyes. Therefore, safety measures such as personal protective equipment (PPE) and proper laboratory ventilation are essential during its use.


To ensure the highest quality and consistent performance, tosyl chloride should be sourced from reputable manufacturers. High-purity grades are necessary for sensitive applications in research and drug development.


In conclusion, tosyl chloride (CAS 98-59-9) is an invaluable reagent in organic synthesis, enabling chemists to explore new chemical spaces and develop innovative molecules. Its significance in the pharmaceutical industry and beyond underscores the importance of sourcing high-quality materials from trustworthy suppliers.


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