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Nov . 01, 2024 01:38 Back to list

Lidocaine Hydrochloride CAS 73-78-9 Supplier Quality and Specifications Information



Lidocaine Hydrochloride A Comprehensive Overview of Its Production and Applications


Lidocaine hydrochloride, identified by its CAS number 73-78-9, is a widely used local anesthetic and antiarrhythmic medication that has been a staple in medical practice for decades. Manufactured through a combination of organic synthesis and rigorous quality control processes, lidocaine hydrochloride is critical in various medical applications, including dentistry, surgery, and emergency medicine.


Chemistry and Properties


Lidocaine, chemically known as 2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide, is a member of the amino amide class of local anesthetics. It is a white crystalline solid with a molecular formula of C14H22N2O and a molecular weight of 234.34 g/mol. The hydrochloride salt enhances the solubility of lidocaine in water, which is essential for its use in injectable forms. This solubility allows for rapid absorption into the bloodstream, providing quick onset of action which is particularly advantageous during surgical procedures.


Manufacturing Process


The production of lidocaine hydrochloride involves several synthesis steps, beginning with the reaction of 2,6-dimethylaniline with chloroacetyl chloride. This intermediate is then treated with diethylamine to yield lidocaine base. The final step involves the addition of hydrochloric acid to form lidocaine hydrochloride, ensuring its stability and solubility for further medical application.


Manufacturers utilize advanced techniques, including high-performance liquid chromatography (HPLC) and infrared spectroscopy, to monitor the purity and quality of the product. Stringent quality control measures are vital, as impurities can lead to adverse effects.


Applications in Medicine


lidocaine hydrochloride cas 73-78-9 manufacturer

Lidocaine Hydrochloride CAS 73-78-9 Supplier Quality and Specifications Information

Lidocaine hydrochloride is primarily known for its local anesthetic properties. Its ability to block nerve signals makes it invaluable during various medical procedures. In dental practices, it is often used to numb the area around the teeth, providing relief during fillings and extractions. In surgical settings, lidocaine can be administered as a nerve block or infiltration anesthetic to minimize patient discomfort.


Additionally, lidocaine serves as an antiarrhythmic agent. It is employed in the treatment of certain types of ventricular arrhythmias, aiding in the stabilization of cardiac rhythm during emergencies. The quick action of lidocaine makes it a first-line treatment in cases of cardiac arrest.


Regulatory Aspects and Safety Considerations


As a pharmaceutical substance, lidocaine hydrochloride is subject to rigorous regulation by agencies such as the U.S. Food and Drug Administration (FDA) and the European Medicines Agency (EMA). These organizations set strict guidelines for the production, labeling, and use of lidocaine to ensure patient safety.


Despite its widespread use, lidocaine is not without risks. Potential side effects can include allergic reactions, cardiac toxicity, and neurological complications if used improperly. Therefore, medical professionals must administer it with caution and monitor patients closely for any adverse reactions.


Conclusion


In conclusion, lidocaine hydrochloride (CAS 73-78-9) is a vital anesthetic and antiarrhythmic agent with a well-established place in modern medicine. Its effective manufacturing practices, coupled with stringent regulatory oversight, ensure that it remains a safe and reliable choice for healthcare providers. As research continues, future developments in its formulation and application may further enhance its utility in clinical settings.


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