Pralmorelin(GHRP-2), with the molecular formula C42H49N9O5, is a white or almost white powder, odorless, slightly bitter, and easily soluble in solvents such as water and methanol. It is a peptide like substance with typical β- Folding structure. GHRP-2 peptide is composed of six amino acids, including histidine (His), arginine (Arg), aspartic acid (Asp), alanine (Ala), cysteine (Cys), and phenylalanine (Phe). It has good thermodynamic stability and is not easily degraded at room temperature. The thermal decomposition temperature at high temperatures is approximately 280 ℃. Meanwhile, the solubility of the product is relatively high, with a solubility of 10mg/mL in water at 25 ℃. GHRP2 peptide is an artificial drug, also known as GHRP-2 acetate, which is a compound that promotes the synthesis and release of human growth hormone. It is a peptide composed of 6 amino acids and has significant physiological effects. Shaanxi BLOOM Tech Co., Ltd has ghrp 2 peptides for sale. You can send an email to inquire about the Ghrp 2 peptide price.

Pralmorelin is a man-made drug, also known as GHRP-2 (growth hormone releasing peptide-2), which can promote the synthesis and release of human growth hormone, and has various physiological effects. In clinical practice, it has been used in the treatment of a variety of diseases, all of which will be described in detail below.

1. Children with poor growth and development:

Children's stunted growth and development is a common endocrine system disease in children, which is mainly manifested as being lower than the average height of peers. It can promote the growth and development of children, increase height and weight by stimulating the synthesis and release of growth hormone. A number of studies have shown that it can effectively promote the growth of children and reduce the occurrence of scoliosis and bone and joint deformities in patients with growth hormone deficiency.

2. Muscle weakness:

Myasthenia is a neuromuscular disorder characterized by muscle weakness, fatigue, and motor dysfunction. It improves muscle strength and endurance and improves motor function in patients with muscle weakness. A clinical trial showed that product significantly improved muscle strength and endurance and reduced fatigue in patients with myasthenia.

4. Skin bumps:

Cutaneous dyskeratosis, also known as benign keratinomatosis of the skin, pearly sweat blisters or skin pimples, is a common abnormal keratinization disease. It can promote cell growth and division, thereby helping to restore the skin's normal cell renewal process and improve the symptoms of patients with pimples. A study showed that it can effectively improve the symptoms of patients with skin pimples and reduce the occurrence of skin sweat blisters.

5. Malnutrition:

Malnutrition is a series of clinical manifestations caused by insufficient intake or malabsorption of nutrients due to poor dietary habits or chronic diseases. It can stimulate the gastrointestinal tract to secrete gastric acid, pancreatic juice and intestinal juice, promote nutrient absorption, increase appetite and improve malnutrition. One study showed that was able to significantly improve weight and height in malnourished patients.

6. Hypoglycemia:

Hypoglycemia is a metabolic disorder characterized by low blood sugar levels. Pralmorelin stimulates the release of insulin and can raise blood sugar levels, treating hypoglycemia. A number of studies have shown that it has a significant effect in the treatment of hypoglycemia, and can effectively improve the blood sugar level of patients.

7. Liver damage:

The liver is the largest internal organ in the human body and is responsible for the synthesis and metabolism of various substances. Liver injury is a common disease, including hepatitis, cirrhosis and other manifestations. It can promote the growth and regeneration of liver cells, repair damaged liver tissue, and treat liver damage. A clinical trial showed that it can significantly improve the clinical symptoms of patients with liver damage, and reduce the degree of liver function damage and liver cell necrosis.

8. Cardiovascular disease:

Cardiovascular disease is a disease caused by dysfunction of the cardiovascular system, including coronary heart disease, myocardial infarction and other manifestations. It can promote the growth and repair of myocardium, and can reduce the load pressure on the heart, thereby improving cardiovascular diseases. A study showed that it can reduce cardiac load pressure in patients with coronary heart disease, and improve myocardial contractility and cardiac output.

In conclusion, GHRP 2 powder is a multifunctional artificial drug with multiple uses, including the treatment of children with poor growth and development, muscle weakness, dyskeratosis, malnutrition, hypoglycemia, liver damage, and cardiovascular disease. In clinical practice, it has been widely used and achieved good curative effect. However, the use of it also has some side effects and safety issues, and it needs to be used under the guidance of a doctor.

Pralmorelin is a man-made drug, also known as GHRP-2 (growth hormone releasing peptide-2), which can promote the synthesis and release of human growth hormone, and has various physiological effects. In clinical practice, it has been used in the treatment of many diseases. The synthesis of it can be divided into two steps: the synthesis of precursor peptide and the conversion of precursor peptide into it. The synthesis methods of these two steps will be introduced respectively below.

Ghrp-2 Peptides For Weight Loss For Sale CAS 158861-67-7

1. Synthesis of precursor peptide:

The precursor peptide of it is a polypeptide composed of 28 amino acid residues, which can be synthesized by solid-phase synthesis technology.

In solid-phase synthesis, amino acids are added to a carrier (usually polystyrene or polyethylene glycol) and reacted to link them into polypeptide chains. Solid-phase synthesis requires the use of protecting groups to prevent the attachment of amino acids in other parts of the reaction. In the synthesis, every time an amino acid is added, steps such as deprotection reaction, washing and compounding are required, and finally the polypeptide is obtained. The specific steps are as follows:

(1) Select the appropriate carrier: choose a polymer with high carrier density and good reactivity as the carrier.

(2) Activated carrier: Activate the carrier so that it can be connected to the first amino acid.

(3) Adding a protecting group: adding a protecting group to the carrier to prevent other amino acids from being connected in the reaction.

(4) Adding the first amino acid: select the first amino acid and connect it to the carrier through an activator.

(5) Repeated addition of amino acids: Add other amino acids in sequence, and each amino acid needs to remove its protective group before adding.

(6) Depeptide: Peel off the peptide from the carrier.

Through the above steps, the precursor peptide polypeptide of it can be obtained.

2. Conversion of precursor peptide to product:

The precursor peptide of product can be converted into product by various methods such as cleavage method, liquid phase synthesis method and chemical synthesis method, which will be introduced one by one below.

(1) cutting method

Cleavage is a commonly used method for the conversion of precursor peptides. The precursor peptide is treated with heating and acid hydrolysis to cause a cleavage reaction in an acidic environment, thereby obtaining the target product. The specific steps are as follows:

Step 1: adding the precursor peptide into the acidic solution and heating for reaction.

Step 2: Wait for the reaction to end, and cool down the solution.

Step 3: Remove by-products and organic solvents by physical or chemical methods.

The advantages of adopting the cleavage method to synthesize Pralmorelin are simple operation and high purity. But it takes a certain amount of time to obtain the target product, and this method produces some waste materials.

(2) Liquid phase synthesis method

Liquid phase synthesis is a commonly used synthesis method. It prepares product by first modifying some residues on the structure of the precursor peptide, and then linking the precursor peptide with the target product. The specific steps are as follows:

Step 1: Modifying the precursor peptide: modifying some residues in the structure of the precursor peptide that need to be modified by chemical reaction or enzyme catalysis.

Step 2: link the modified precursor peptide to the target product: link the modified precursor peptide to the activated target product by reaction or enzyme catalysis.

The advantage of using the liquid phase synthesis method to prepare it is that the reaction speed is fast and the synthesis efficiency is also high. But the operation is complicated and the cost is high.

(3) Chemical synthesis method

Chemical synthesis is a commonly used precursor peptide conversion method, which converts the precursor peptide into product through chemical reactions in the steps of deprotection, oxidation, and reduction. The specific steps are as follows:

Step 1: Removing the protecting group: remove the protecting group on the precursor peptide by an appropriate method.

Step 2: Oxidation and reduction reactions: Use appropriate oxidizing and reducing agents to react specific positions on the precursor peptide.

Step 3: adding functional groups: adding some functional groups of the target product to the precursor peptide after oxidation and reduction treatment.

Step 4: extraction and purification: the product is extracted and purified by chromatography or other techniques.

The advantage of using the chemical synthesis method to prepare it is that the synthesis efficiency is high and the cost is low. However, this method requires multiple treatments and purifications and produces some hazardous waste.

Summarize:

It is a polypeptide drug, and its synthesis method is diverse, mainly divided into two steps: the synthesis of precursor peptide and the conversion of precursor peptide into product. In the synthesis of precursor peptides, solid-phase synthesis techniques are often used. In the conversion of precursor peptides to product, commonly used methods include cleavage, liquid phase synthesis, and chemical synthesis, each of which has its own advantages and disadvantages. When choosing a synthetic method, it is necessary to consider comprehensively according to the specific situation in order to achieve the goals of high efficiency, economy and environmental protection.

Pralmorelin is a man-made drug also known as GHRP-2 (growth hormone releasing peptide-2) with the chemical name D-alanyl-3-(2-naphthyl)-D-alanyl-L-alpha-aspartyl-L -phenylalanyl-L-lysinamide. The substance has a variety of physiological effects, mainly by promoting the synthesis and release of human growth hormone to play a therapeutic role.

it is a polypeptide composed of 28 amino acid residues, which are connected to each other by peptide bonds. It has a large molecular weight and complex structure. Due to the existence of many different amino acid residues and side chain groups, it has great research value in terms of derivatization properties, biological activities and clinical applications. The structural features of product will be introduced one by one below.

 1. Amino acid residues:

The polypeptide chain of it is composed of different amino acid residues, which can be represented by single-letter codes, including: A, C, D, E, F, G, H, I, K, L, M, N, P, Q, R, S, T, V, W, Y. These amino acids have an amino group, a carboxyl group, and a side chain group, which form a peptide chain through peptide bonds. In the polypeptide chain of product, the sequence and composition of amino acid residues directly affect its biological activity and pharmacological effect.

(1) D-alanine:
It contains some very rare amino acid residues, such as D-alanine. D-alanine and L-alanine are two stereoisomers with different spatial structures and thus different chemical and biological activities. D-alanine can enhance the stability of product, and promote its peptide chain folding and effect in vivo.

(2) L-alpha-aspartyl:
L-alpha-aspartyl is a secondary amino acid with a carboxyl group and two negatively charged carboxylic acid side chains. It plays an important role in the polypeptide chain of product and can form ionic bonds with other amino acid residues, thereby affecting its molecular structure and biological activity. In addition, L-alpha-aspartyl can also participate in metabolism, such as the tricarboxylic acid cycle and glucose production.

(3) Phenylalanyl:
Phenylalanyl is an aromatic amino acid consisting of phenyl and carboxyl side chains. In the polypeptide chain of it, the presence of Phenylalanyl can increase its hydrophilicity and lipophilicity, thereby affecting its solubility and bioavailability. In addition, Phenylalanyl is also involved in multiple physiological processes, such as protein synthesis and enzyme-catalyzed reactions.

(4) L-Lysine:
L-lysine is an amino acid residue with a cationic side chain, which plays an important role in the molecular structure and biological activity of it. L-lysine can form ionic bonds with negatively charged amino acid residues, thereby affecting the folding and stability of the product peptide chain. In addition, L-lysine also participates in various metabolic processes in organisms and can promote protein synthesis.

2. Peptide bond

The 28 amino acid residues of pralmorelin are connected to each other by peptide bonds, which are formed by condensation reactions between amino groups and carboxyl groups in amino acids. The formation of peptide bonds allows the amino acid residues to form a linear arrangement, forming a peptide chain. In the peptide chain of product, the position and nature of the peptide bond directly affect its molecular structure and biological activity.

The formation of peptide bonds is achieved through the formation of condensation reactions between carboxyl groups and amino groups. During this process, a molecule of water is lost and a new peptide bond is formed. In product, the formation of peptide bonds connects 28 amino acid residues into a linear peptide chain, and forms strong hydrogen bonds and van der Waals forces. These interactions stabilize the molecular structure of product, forming a regular spatial conformation.

3. Side chain groups

The amino acid side chain groups in the product polypeptide chain have different chemical reactivity and biological activity at different positions. Side chain groups can affect the molecular structure, solubility and biological activity of product, thus playing an important physiological role. The structural characteristics and biological significance of some amino acid side chain groups in the it polypeptide chain will be introduced one by one below.

(1) 2-Naphthalanine
2-Naphthalanine is an important amino acid residue in the polypeptide chain of it, and its side chain contains a benzene ring structure and an alanine group. The presence of 2-naphthalanine increases the solubility and bioavailability of it, and at the same time can enhance its affinity with receptors. In addition, 2-naphthalanine also has the effect of stimulating the release of growth hormone and regulating energy metabolism.

(2) L-Glutamine
L-Glutamine is a nonpolar amino acid residue containing an amino group and a carboxylamine group in its side chain. L-Glutamine has important biological significance in the polypeptide chain of product, which can enhance its biological activity and stability, and participate in metabolic processes, such as the tricarboxylic acid cycle and glucose production.

(3) L-tryptophan
L-tryptophan is a polar amino acid with an aromatic ring structure, and its side chain includes an indole ring, an amino group and a carboxyl group. L-tryptophan plays an important biological role in it, such as promoting the synthesis and release of growth hormone, improving cardiovascular health and enhancing immunity, etc.

(4) L-Aspartic Acid
L-Aspartic acid is an amino acid residue with a hydroxyl group and a negative charge, which can form ionic bonds with other amino acid residues. L-Aspartic acid plays an important regulatory role in the polypeptide chain of it, which can enhance its biological activity and stability, and participate in metabolic processes, such as glycogen synthesis and enzyme-catalyzed reactions.

In short, the molecular structure of it is very complex, consisting of 28 amino acid residues and many side chain groups. These structural features directly affect its pharmacological properties and clinical applications. Therefore, the study of the structural characteristics of Pralmorelin is of great significance for the in-depth understanding of its pharmacological effects and clinical applications.