Blog
-
Pulmonary Administration of GW0742
Pulmonary emphysema is a disease in which lung alveoli are irreversibly damaged, thus compromising lung function. Our previous study revealed that all-trans-retinoic acid (ATRA) induces the differentiation of human lung alveolar epithelial type 2 progenitor cells and repairs the alveoli of emphysema model mice. ATRA also reportedly has the ability to activate peroxisome proliferator-activated receptor (PPAR) beta/delta. A selective PPARbeta/delta ligand has been reported to induce the differentiation of human keratinocytes during wound repair. Here, we demonstrate that treatment using a high-affinity PPARbeta/delta agonist, GW0742, reverses the lung tissue damage induced by elastase in emphysema-model mice and improves respiratory function. Mice treated with elastase, which collapsed their alveoli, were then treated with either 10% dimethyl sulfoxide (DMSO) in saline (control group) or GW0742 (1.0 mg/kg twice a week) by pulmonary administration. Treatment with GW0742 for 2 weeks increased the in vivo expression of surfactant proteins A and D, which are known alveolar type II epithelial cell markers. GW0742 treatment also shortened the average distance between alveolar walls in the lungs of emphysema model mice, compared with a control group treated with 10% DMSO in saline. Treatment with GW0742 for 3 weeks also improved tissue elastance (cm H2O/mL), as well as the ratio of the forced expiratory volume in the fi rst 0.05 s to the forced vital capacity (FEV 0.05/FVC). In each of these experiments, GW0742 treatment reversed the damage caused by elastase. In conclusion, PPARbeta/delta agonists are potential therapeutic agents for pulmonary emphysema.Čitaj više -
What is semaglutide？
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists, or GLP-1 RAs. It mimics the GLP-1 hormone, released in the gut in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood sugar (glucose). For that reason, health care providers have used semaglutide for more than 15 years to treat Type 2 diabetes. But GLP-1 in higher amounts also interacts with the parts of the brain that suppress your appetite and signal you to feel full. When used in conjunction with diet and exercise, it can cause significant weight loss — and a reduced risk of cancer,diabetes and heart disease — in people who are obese or overweight.Čitaj više -
Semaglutide market report in 2023
Semaglutide (CAS No: 910463-68-2), belongs to GLP-1 RAs(glucagon-like peptide-1 receptor agonists), is an antidiabetic medication used for the treatment of type 2 diabetes and an anti-obesity medication used for long-term weight management, developed by Novo Nordisk in 2012. The compound patent of will be expiried in 2026. Semaglutide is quite popular and has a very promising market demand due to its excellent function (for treating diabetes and losing weight) with no obvious side-effect and advanced technology.Čitaj više -
910463-68-2 Usage
Semaglutide, sold under the brand name Ozempic among others, is an anti-diabetic medication used for the treatment of type 2 diabetes and chronic weight management. Semaglutide acts like human glucagon-like peptide-1 (GLP-1) such that it increases insulin secretion, thereby increasing sugar metabolism. It is distributed as a metered subcutaneous injection in a prefilled pen, or as an oral form. One of its advantages over other antidiabetic drugs is that it has a long duration of action, thus, only once-a-week injection is sufficient.Čitaj više -
Medications Containing Semaglutide Marketed for Type 2 Diabetes or Weight LossWhat is semaglutide?
Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. It mimics the GLP-1 hormone that is released in the gastrointestinal tract in response to eating. One role of GLP-1 is to prompt the body to produce more insulin, which reduces blood glucose (sugar). GLP-1 in higher amounts also interacts with the parts of the brain that reduce appetite and signal a feeling of fullness.There are currently three FDA-approved semaglutide products:Ozempic injection and Rybelsus tablets are approved to lower blood sugar levels in adults with type 2 diabetes mellitus, in addition to diet and exercise. Ozempic is also approved to reduce the risk of heart attack, stroke, or death in adults with type 2 diabetes mellitus and known heart disease.Čitaj više -
Premium Semaglutide CAS 910463-68-2: Superior Blood Sugar Regulation Solution
Introducing premium Semaglutide CAS 910463-68-2, an exceptional compound meticulously designed to regulate blood sugar levels with unmatched superiority. With its pharmaceutical-grade composition, this remarkable solution has been trusted and relied upon in the pharmaceutical industry for its outstanding performance and consistently reliable results.Čitaj više -
What is Semaglutide?
Semaglutide is a medication that was approved by the U.S. Food and Drug Administration (FDA) in June 2021 for weight loss. It is combined with a low-calorie diet and exercise program to help people lose weight. Semaglutide is a GLP-1 agonist that works by increasing insulin release, decreasing glucagon release, delaying gastric emptying, and reducing appetite. Semaglutide is not suitable for people with type 1 diabetes.Čitaj više -
Is semaglutide effective for weight loss if you don't have diabetes?
Research suggests semaglutide is safe and effective for weight loss in people with or without type 2 diabetes. Wegovy is the only semaglutide product approved for weight loss. But to get a prescription, you must meet certain health-related criteria.Semaglutide belongs to the glucagon-like peptide-1 (GLP-1) receptor agonist drug class. In the United States, semaglutide is not available as a generic product. Three semaglutide brand names are available, and you need a prescription to obtain all of them.Čitaj više -
Semaglutide (Subcutaneous Route)
Semaglutide injection is used to treat type 2 diabetes. It is used together with diet and exercise to help control your blood sugar. This medicine is also used to lower the risk of heart attack, stroke, or death in patients with type 2 diabetes, obesity, and heart or blood vessel disease. Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist.Čitaj više