A Comprehensive Guide to Tosyl Chloride (CAS 98-59-9) and Its Manufacturers

Tosyl chloride, also known as p-toluenesulfonyl chloride, is a vital chemical intermediate used in various organic synthesis processes. With the CAS number 98-59-9, it plays a crucial role in the pharmaceutical, agricultural, and chemical industries. This article explores the significance of tosyl chloride, its applications, and a brief overview of the manufacturers producing this essential compound.

What is Tosyl Chloride?

Tosyl chloride is a colorless to pale yellow liquid with a pungent odor. This sulfonate derivative contains a sulfonyl group attached to a toluene ring, rendering it highly reactive. It is soluble in organic solvents like dichloromethane and acetone but reacts with water, producing p-toluenesulfonic acid. This reactivity makes it an excellent reagent for introducing tosyl groups into various organic molecules, thus protecting functional groups during synthesis reactions.

Applications of Tosyl Chloride

1. Protecting Group Tosyl chloride is widely used as a protecting group for alcohols and amines in organic synthesis. By converting these functional groups into their corresponding tosyl derivatives, chemists can prevent unwanted reactions and ensure selective transformations.

2. Formation of Leaving Groups In nucleophilic substitution reactions, tosyl groups serve as excellent leaving groups. The conversion of alcohols and amines to tosylates enhances their reactivity, allowing for the formation of a broader range of compounds.

3. Synthesis of Pharmaceuticals Tosyl chloride is integral in drug synthesis, facilitating the production of various pharmaceutical intermediates. Its ability to modify functional groups makes it an essential reagent in the development of new medications.

4. Agricultural Chemicals The compound also finds applications in producing agrochemicals. Its reactivity is useful for synthesizing herbicides, insecticides, and other crop protection products.

5. Polymer Chemistry In polymer chemistry, tosyl chloride is used to functionalize polymer backbones. This modification enhances the properties of polymers, making them suitable for specific applications.

With its extensive applications, numerous manufacturers produce tosyl chloride worldwide. Here is a list of prominent companies known for their high-quality production

1. Sigma-Aldrich (Merck) A leader in the field of chemistry and life sciences, Sigma-Aldrich offers a wide range of organic chemicals, including tosyl chloride. They provide detailed product specifications and support for researchers and manufacturers.

2. TCI America Known for its commitment to providing high-purity industrial chemicals, TCI America supplies tosyl chloride with consistent quality. They focus on customer satisfaction and technical support, ensuring researchers have access to the best products.

3. Alfa Aesar A part of Thermo Fisher Scientific, Alfa Aesar produces high-quality tosyl chloride for various applications. Their extensive catalog covers a broad range of chemicals, catering to both research and industry needs.

4. Fisher Scientific This manufacturer is well-regarded for its reliable chemicals and reagents. With a robust supply chain, Fisher Scientific provides consistent access to tosyl chloride and other essential reagents.

5. Huaian Lihua Chemical Co., Ltd. This company is recognized for its production of specialty chemicals, including tosyl chloride. They have established a reputation for offering competitive pricing while maintaining high-quality standards.

Conclusion

Tosyl chloride (CAS 98-59-9) is an indispensable reagent in organic chemistry, with a wide range of applications spanning pharmaceuticals, agriculture, and polymer science. The continued demand for this chemical has led to a vibrant market filled with numerous manufacturers dedicated to producing high-quality products. As research and development in chemistry progress, tosyl chloride will undoubtedly maintain its relevance in various chemical processes, contributing significantly to advancements in multiple industries.