Isopropyl Acetoacetate Overview, Applications, and Suppliers

Isopropyl acetoacetate, with the chemical formula C7H14O3 and CAS number 542-08-5, is a versatile compound that has garnered significant attention in various industries due to its unique properties and wide-ranging applications. This colorless liquid is often utilized as an intermediate in organic synthesis, primarily for the production of pharmaceuticals, agrochemicals, and flavorings.

Chemical Properties

Isopropyl acetoacetate is an ester derived from acetoacetic acid and isopropyl alcohol. Its structure features a carbonyl group (C=O) and an ester functional group, which contribute to its reactivity. The presence of ketonic and ester functionalities makes it a valuable building block in synthetic chemistry. It possesses a boiling point around 190°C and a density of 1.025 g/cm³, making it a relatively stable compound under standard conditions.

Applications

1. Pharmaceutical Industry One of the primary applications of isopropyl acetoacetate is as an intermediate in the synthesis of active pharmaceutical ingredients (APIs). It is used in the production of various drugs, particularly those dealing with central nervous system disorders, antipyretics, and anti-inflammatory medications. Its ability to undergo various chemical reactions such as alkylation, acylation, and condensation makes it useful for creating complex molecular structures.

2. Agrochemicals In the agriculture sector, isopropyl acetoacetate serves as a precursor in the formulation of pesticides and herbicides. Its role in enhancing the solubility and bioavailability of active ingredients is crucial for the effectiveness of agrochemical products. The compound can also be involved in the synthesis of plant growth regulators, contributing to improved crop yield and quality.

3. Flavor and Fragrance The cosmetic and food industries utilize isopropyl acetoacetate for creating flavoring agents and fragrances. Its pleasant odor and flavor profile make it an attractive choice for use in perfumes and food additives. The compound can be employed to replicate fruity notes, adding depth and complexity to various formulations.

4. Chemical Research Isopropyl acetoacetate is also a significant reagent in chemical research, particularly in the development of new synthetic methodologies. Its reactivity allows chemists to explore innovative pathways for synthesizing other compounds, thus driving forward research in organic chemistry.

Safety and Handling

Although isopropyl acetoacetate is generally considered safe for use in controlled environments, standard safety measures should be observed. It is advisable to handle the compound in a well-ventilated area, wearing appropriate personal protective equipment (PPE) such as gloves and goggles. In case of skin or eye contact, it is important to rinse with plenty of water and seek medical advice if irritation persists.

Suppliers

Several chemical suppliers across the globe specialize in providing high-quality isopropyl acetoacetate. When sourcing this compound, it is essential to consider not only the price but also the reputation of the supplier, product purity, and compliance with regulatory standards. Reliable suppliers often provide comprehensive product data sheets (PDS) that detail the specifications, safety data, and application recommendations for their products.

Prominent chemical companies that supply isopropyl acetoacetate include

- Sigma-Aldrich Recognized for their extensive catalog of chemicals and reagents, they offer high-purity isopropyl acetoacetate suitable for various applications. - Acros Organics This supplier focuses on providing specialized chemicals for laboratory research and provides detailed information about their products. - TCI Chemicals A global supplier known for high-quality chemicals, TCI offers isopropyl acetoacetate in various quantities, catering to both small research labs and large-scale production needs.

Conclusion

Isopropyl acetoacetate is a versatile compound with a wide range of applications across different industries, particularly in pharmaceuticals, agrochemicals, and flavor and fragrance production. Understanding its properties, applications, and the importance of sourcing it from reputable suppliers is crucial for businesses and researchers alike. Its unique chemical behavior continues to inspire innovation and development within the field of organic chemistry.