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dec . 15, 2024 23:58 Back to list

Lidocaine Hydrochloride CAS 73-78-9 Source and Application in Pharmaceuticals



Lidocaine Hydrochloride An Overview of Its Properties and Uses


Lidocaine hydrochloride, identified by its CAS number 73-78-9, is a widely used local anesthetic that has garnered significant attention in medical and pharmaceutical applications. This compound, with the molecular formula C14H22ClN2O, is a white crystalline powder that is soluble in water, making it highly effective for various therapeutic uses.


Properties of Lidocaine Hydrochloride

Lidocaine hydrochloride possesses several unique properties that contribute to its effectiveness as an anesthetic. It has a rapid onset of action, typically taking effect within minutes of administration. This feature is particularly critical in surgical procedures where immediate pain relief is needed. The duration of its numbing effect can last from one to several hours, depending on the dosage and the specific formulation used.


As an amino amide local anesthetic, lidocaine works by blocking sodium channels in the nerve membranes. This inhibition prevents the transmission of nerve impulses, effectively reducing pain sensation in the area where it is applied. The safety profile of lidocaine is generally favorable, with adverse effects being rare when used appropriately. Common side effects may include localized irritation and allergic reactions, but serious complications are uncommon.


Medical Applications


Lidocaine hydrochloride is commonly used in various medical settings. Its primary application is to provide local anesthesia for minor surgical procedures, dental work, and other interventions where pain management is critical. In dentistry, lidocaine is often administered through injections to numb the gums and surrounding tissues, allowing for pain-free procedures such as tooth extractions or root canals.


china lidocaine hydrochloride cas 73-78-9

china lidocaine hydrochloride cas 73-78-9

Beyond its role in surgery, lidocaine is also effective in managing chronic pain conditions. It is used in transdermal patches for patients suffering from neuropathic pain, postherpetic neuralgia, and other painful conditions. The lidocaine patches allow for continuous drug delivery, providing localized pain relief without the systemic side effects associated with oral medications.


Furthermore, lidocaine has applications beyond local anesthesia. It is used as an antiarrhythmic agent to treat certain types of life-threatening ventricular arrhythmias. In emergency medicine, intravenous lidocaine can stabilize the heart rhythm in patients experiencing cardiac arrest. This dual functionality as both an anesthetic and an antiarrhythmic agent underscores the compound's versatility in clinical practice.


Safety and Regulations


While lidocaine hydrochloride is generally safe when used as directed, it is essential for healthcare providers to be aware of the potential risks. Overdose or improper administration can lead to systemic toxicity, resulting in symptoms such as dizziness, seizures, and cardiovascular disturbances. Therefore, careful monitoring and dosing are crucial, especially in high-risk populations such as the elderly or those with pre-existing health conditions.


Regulatory agencies, including the FDA, oversee the approval and monitoring of lidocaine formulations to ensure their safety and efficacy for public use. Numerous formulations, including injectable solutions, topical creams, and patches, are available, catering to various medical needs and preferences.


Conclusion


In summary, lidocaine hydrochloride (CAS 73-78-9) is a critical component in the modern medical landscape, offering reliable local anesthesia and emergency cardiac support. Its unique properties and wide range of applications make it an invaluable tool for healthcare professionals. As ongoing research continues to explore new formulations and applications, lidocaine remains a cornerstone of pain management and procedural anesthesia, enhancing patient comfort and care outcomes in numerous clinical settings.


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