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Dek . 17, 2024 13:05 Back to list

3-chloropyridine cas 626-60-8



3-Chloropyridine An Overview


3-Chloropyridine, with the chemical formula C5H4ClN and CAS number 626-60-8, is a chlorinated derivative of pyridine. This compound is characterized by its aromatic structure, where a chlorine atom substitutes the hydrogen at the third position of the pyridine ring. Pyridine itself is a six-membered heterocyclic compound that contains one nitrogen atom and is widely used in industrial applications and organic synthesis.


Properties and Characteristics

3-Chloropyridine is a colorless to yellow liquid at room temperature, exhibiting a distinct odor typical of pyridine derivatives. It has a boiling point of approximately 158°C and a melting point around -33°C. The density of 3-chloropyridine is about 1.1 g/cm³, and it is partially soluble in water, while being fully soluble in organic solvents such as ethanol and ether. The presence of the chlorine atom enhances its reactivity, making it an important intermediate in various chemical reactions.


Synthesis


The synthesis of 3-chloropyridine can be achieved through several methods, including chlorination of pyridine under controlled conditions. One common synthetic route involves electrophilic aromatic substitution, where a chlorine electrophile is introduced to the pyridine ring. This reaction typically requires the presence of a catalyst, such as iron(III) chloride or aluminum chloride, to facilitate the substitution reaction. Other synthetic pathways may involve the chlorination of related pyridine derivatives or the use of various chlorinating agents to directly introduce the chlorine atom to the desired position.


Applications


3-chloropyridine cas 626-60-8

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3-Chloropyridine plays a significant role in the pharmaceutical and agrochemical industries. It serves as a building block for the synthesis of various biologically active compounds, including pharmaceuticals that target a range of medical conditions. The compound is frequently utilized as a precursor in the development of insecticides, herbicides, and other agrochemicals that help enhance agricultural productivity.


In addition to its uses in the pharmaceutical and agrochemical sectors, 3-chloropyridine is valuable in the production of dyes, pigments, and other chemical intermediates. Its unique electronic properties and reactivity make it an essential component in the synthesis of heterocyclic compounds that are crucial for the development of new materials and technologies.


Safety and Handling


While 3-chloropyridine is an essential compound in many chemical processes, it is also important to handle it with caution due to its potential health hazards. It can be harmful if inhaled, ingested, or absorbed through the skin. Symptoms of exposure may include respiratory issues, skin irritation, and eye damage. Therefore, proper safety precautions must be followed, such as using personal protective equipment (PPE), working in a well-ventilated area, and ensuring that safety data sheets (SDS) are readily available.


Conclusion


In summary, 3-chloropyridine is a versatile and important compound in organic chemistry, with far-reaching applications in pharmaceuticals and agrochemicals. Its unique structure and properties make it a key building block in the synthesis of various chemical products. As research continues to advance, the potential uses for 3-chloropyridine may expand further, showcasing the significance of this compound in both industry and academia. Understanding its properties, synthesis methods, and applications highlights its relevance in modern chemistry and its role in the development of new technologies and solutions to global challenges.


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